Original Articles Vol. 3 No. 3 (2026): Bioscience Insights Published 2026-10-31

EXPLORING CORYDALIS GOVANIANA VAR. SWATENSIS AS A SOURCE OF NATURAL BIOACTIVE COMPOUNDS: IMPLICATIONS FOR INFECTIOUS DISEASE MANAGEMENT AND PUBLIC HEALTH

Authors

  • Safeena Wahid Department of Chemical and Life Sciences, Qurtuba University of Science and Information Technology, Peshawar, Pakistan. Pakistan Author
  • Dr. Muhammad Adil Department of Botany, University of Swat, Pakistan. Pakistan Author
  • Dr. Ambrin Department of Chemical and Life Sciences, Qurtuba University of Science and Information Technology, Peshawar, Pakistan. Pakistan Author
  • Amina Zaib Department of Chemical and Life Sciences, Qurtuba University of Science and Information Technology, Peshawar, Pakistan. Pakistan Author
  • Fozia Naz Department of Chemistry, Shaheed Benazir Bhutto Women University, Peshawar, Pakistan. Pakistan Author
  • Ayesha Bibi Department of Chemical and Life Sciences, Qurtuba University of Science and Information Technology, Peshawar, Pakistan. Pakistan Author
  • Tania Jabeen Department of Chemistry, Shaheed Benazir Bhutto Women University, Peshawar, Pakistan Pakistan Author
  • Naveeda Bibi Department of Chemical and Life Sciences, Qurtuba University of Science and Information Technology, Peshawar, Pakistan. Pakistan Author
56 views 9 downloads

Abstract

This study investigated the extraction yield, chemical fingerprint profiles, antibacterial activity, and preliminary cytotoxicity of Corydalis govaniana var. swatensis. Three plant-material batches were examined, and the crude extract was compared with three fractions (F1, F2, and F3). The mean extraction yield was 12.00 ± 0.40%. Chemical profiling showed distinct relative contributions of features P1, P2, and P3 across the preparations. Fraction F2 demonstrated the lowest median minimum inhibitory concentrations against Organisms A and B (64 and 256 µg/mL, respectively). It also showed the lowest mean CC₅₀ (433.84 µg/mL), indicating comparatively greater cytotoxicity in the tested cell model. Despite this, F2 exhibited the highest median selectivity indices against Organisms A and B (6.36 and 1.59, respectively). These findings identify F2 as a preparation of interest for further investigation. However, incomplete validation information and unconfirmed feature identities limit interpretation. Further controlled studies are needed to establish reproducibility, chemical identities, and therapeutic relevance.

Keywords

  • Corydalis govaniana var. swatensis; antibacterial activity; phytochemical profiling; minimum inhibitory concentration; cytotoxicity; selectivity index; natural products.

Views & Downloads Statistics (Last 12 Months)

Monthly performance and trends of article views and downloads

Views (12 months)56
Downloads (12 months)9
Article Views PDF Downloads